The 2018–19 Atlético San Luis season is the 6th season in the football club's history.

Atlético San Luis are the current champions of Ascenso MX after winning the Apertura 2018 tournament.

Players and squad numbers last updated on 16 December 2018.

[1]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Players may hold more than one non-FIFA nationality.