The playoffs involved the sixteen teams which qualified between the four first teams of each of the four groups in the 2018–19 Basketball Champions League Regular season.
The group winners will face the fourth qualified teams and the runners-up will play against the third qualified teams.
Winners and runners-up will play the second leg at home.
Each tie in the playoffs, apart from the Final Four games, was played with two legs, with each team playing one leg at home.
The team that scored more points on aggregate, over the two legs, advanced to the next round.