The winners of the competition qualify for the 2019–20 UEFA Europa League Group Stage.
Teams from the fifth-level Belgian Third Amateur Division or lower began in round 1.
Some fifth round ties were reversed as amateur teams (tiers 3 and below) automatically received home advantage in case they met the stadium requirements regarding seating, lighting and safety.
The draw for the sixth round was made on 28 August 2018 and included the 16 teams from the Belgian First Division A, which were all seeded and could not meet each other.
Both Mechelen and Union SG, the two remaining teams from outside the top division managed to qualify for the Semi-finals.