The 2018–19 Big South Conference men's basketball season began with practices in October 2018, followed by the start of the 2018–19 NCAA Division I men's basketball season in November.
On December 21, 2018, Campbell's Chris Clemons became the all-time leading scorer in Big South history.
He passed VMI guard Reggie Williams' 2,556 career point total in a game against Austin Peay.
[3] Liberty, which had started a transition to FBS football in the 2017 season, had initially reached an agreement with the Big South that it would continue to house all of its other sports (except for field hockey and women's swimming, neither of which is sponsored by the Big South) in that conference after becoming classified as an FBS independent from the 2018 season forward.
[4] However, in May 2018, Liberty changed course, announcing that all of its other Big South sports would instead move to the ASUN.