Cambridge United announced they will face ten different opponents during their pre-season schedule.

Source: BBC On 21 June 2018, the League Two fixtures for the forthcoming season were announced.

[29][30] The first round draw was made live on BBC by Dennis Wise and Dion Dublin on 22 October.

[34] On 13 July 2018, the initial group stage draw bar the U21 invited clubs was announced.

[35] The draw for the second round was made live on Talksport by Leon Britton and Steve Claridge on 16 November.