Frank Fabra is ruled out of the 2018 FIFA World Cup after sustaining an anterior cruciate ligament tear in his left knee, also, he will miss the entire 2018 Copa Libertadores.

[1] On June 27 Boca announced that Sebastián Villa is the first signing of the season, after reaching an agreement with Colombian champions Deportes Tolima.

[14] In the second leg of the Round of 16 of Copa Libertadores, Boca won 4–2 against Libertad and advanced to the Quarterfinals, facing Brazilian team Cruzeiro.

In the second leg of the Quarterfinals of Copa Libertadores, Boca drew 1–1 against Cruzeiro and advanced to the Semifinals, facing Brazilian team Palmeiras.

In the first leg of the Semifinals of Copa Libertadores, Boca played a great match and won 2–0 over Palmeiras.

Boca qualified to the Finals of the 2018 Copa Libertadores after defeating Palmeiras, and will face old time rival River Plate in an unprecedented edition of the Superclásico.

Guillermo Barros Schelotto is no longer the coach of Boca, after two years that included two Argentine League trophies.

[18] Cristian Espinoza and Carlos Lampe finished their loans with the club and returned to Villarreal and Huachipato.

On January 2, Boca and Ajax reached an agreement for the transfer of defender Lisandro Magallán.

[22] Boca and Borussia Dortmund reached an agreement for the transfer of defender Leonardo Balerdi.

[24][25] On January 18, Boca and San Lorenzo reached an agreement for the transfer of defender Gino Peruzzi.

[32] Boca purchases a percentage of Lucas Olaza from Talleres (C) and is loaned to Celta de Vigo.

Boca and Zenit Saint Petersburg reached an agreement for the transfer of defensive midfielder Wílmar Barrios.

On March 14, Boca and Fernando Gago agreed to a contract termination; he played 199 games and won 9 titles.

On May 5 Boca advanced to the quarterfinals of Copa de la Superliga by winning 3–1 against Godoy Cruz.

On May 12, Boca draw Vélez Sarsfield 0–0 in the first leg of Copa de la Superliga quarterfinals.

On May 19, Boca draw Argentinos Juniors 0–0 in the first leg of Copa de la Superliga semifinals.

On May 26, Boca won 1–0 against Argentinos Juniors and advanced to the Copa de la Superliga final.

On June 2 Boca played the last match of the season, a 2–0 defeat against Tigre in the final of the Copa de la Superliga.