The season began on 10 August 2018 and concluded on 27 April 2019.
Caernarfon Town were champions in the previous season and were promoted to the Welsh Premier League.
They were replaced by Prestatyn Town who were relegated from the Welsh Premier League and Bangor City who were demoted from the Welsh Premier League.
The bottom three teams from the previous season, Caersws, Llandudno Junction and Queens Park were relegated to the Mid Wales Football League, the Welsh Alliance League and the Welsh National League (Wrexham Area), respectively.
Welsh National League (Wrexham Area) champions, Buckley Town, Welsh Alliance League champions, Conwy Borough and Mid Wales Football League champions, Llanrhaeadr were promoted to the Cymru Alliance.