The 2018–19 DePaul Blue Demons men's basketball team represented DePaul University during the 2018–19 NCAA Division I men's basketball season.

They were led by fourth-year (seventh overall with DePaul) head coach Dave Leitao and played their home games at the Wintrust Arena in Chicago as members of the Big East Conference.

10 seed in the Big East tournament, they lost in the first round to St. John's.

They received a bid to the College Basketball Invitational where they defeated Central Michigan, Longwood, and Coastal Carolina to advance to the championship series against South Florida.

There, in a best-of-three series, they lost to South Florida two games to one.