The 2018–18 DePaul Blue Demons women's basketball team represented DePaul University during the 2018–19 NCAA Division I women's basketball season.

The Blue Demons, led by thirty-third year head coach Doug Bruno, played their home games at the Wintrust Arena as members of the Big East Conference.

[1][2] DePaul won the Big East Conference tournament championship game over Marquette, 74–73.

[3] They were upset in the first round by Missouri State in the NCAA women's tournament.

They won the Big East women's tournament by defeating Marquette in the championship game.