The 2018–19 Duke Blue Devils men's basketball team represented Duke University during the 2018–19 NCAA Division I men's basketball season.

The Blue Devils played their home games at Cameron Indoor Stadium in Durham, North Carolina as a member of the Atlantic Coast Conference.

They received the ACC's automatic bid to the NCAA tournament and reached the Elite Eight, where they lost 68–67 to Michigan State.

They defeated Notre Dame in the quarterfinals of the ACC tournament before losing to North Carolina in the semifinals.

There they defeated Iona, Rhode Island, and Syracuse to advance to the Elite Eight.