The 2018–19 Eastern Illinois Panthers men's basketball team represented Eastern Illinois University during the 2018–19 NCAA Division I men's basketball season.

The Panthers, led by seventh-year head coach Jay Spoonhour, played their home games at Lantz Arena as members of the Ohio Valley Conference.

They lost to UT Martin in the first round of the OVC tournament.

They defeated Tennessee State in the first round of the OVC tournament before losing in the quarterfinals to Austin Peay.

In a vote of conference coaches and sports information directors, EIU was picked to finish in 7th place in the OVC.