The season began on 10 August 2018 and concluded on 15 May 2019; the Europa League and relegation play-offs will take place later that month.

Emmen, De Graafschap and Fortuna Sittard joined as the promoted clubs from the 2017–18 Eerste Divisie.

They replaced Sparta Rotterdam, Twente and Roda JC who were relegated to the 2018–19 Eerste Divisie.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Four teams played for a spot in the 2019–20 UEFA Europa League second qualifying round.