The 2018–19 Mississippi Valley State Delta Devils basketball team represented Mississippi Valley State University in the 2018–19 NCAA Division I men's basketball season.

The Delta Devils were led by fifth-year head coach Andre Payne, and played their home games at the Harrison HPER Complex in Itta Bena, Mississippi as members of the Southwestern Athletic Conference.

They failed to qualify for the 2019 SWAC tournament, as only the top eight teams are eligible to participate.

Due to the ineligibility of Grambling State, the Delta Devils received the No.

8 seed in the SWAC tournament and lost to Arkansas–Pine Bluff in the quarterfinals.