Number in brackets denote the level of respective league in Football in Moldova.
Teams that finished higher on the league in the previous season played their ties away.
In a match, the home advantage was granted to the team from the lower league.
In a match, the home advantage was granted to the team from the lower league.
The home teams in the first legs and the pairs were determined in a draw held on 13 June 2018.
The "home" team (for administrative purposes) was determined by an additional draw held on 9 May 2019.