[6] Munster opened their 2018–19 Pro14 season with a six-try 38–0 victory against South African side Cheetahs in Thomond Park on 1 September 2018.

Rory Scannell, Dave Kilcoyne, Tommy O'Donnell, JJ Hanrahan, Dave O'Callaghan and Man-of-the-Match Darren Sweetnam scored the tries, with Hanrahan adding four conversions, in a match that saw Arno Botha, Mike Haley, Joey Carbery and academy players Shane Daly and Gavin Coombes make their competitive debuts for the province, whilst Neil Cronin also made his first appearance for Munster since March 2015.

[9] In round one of the 2018–19 Champions Cup on 13 October 2018, a try from CJ Stander and five points from the boot of Joey Carbery secured a 10–10 draw in Sandy Park against Exeter Chiefs, in a match in which Dan Goggin and Neil Cronin made their competitive European debuts, whilst Tadhg Beirne, who was Man-of-the-Match, Mike Haley and Joey Carbery made their European debuts for Munster.

[10] One week later, tries from Mike Haley, Rhys Marshall, Joey Carbery, who also kicked four conversions and one penalty in a Man-of-the-Match performance, Sammy Arnold and Andrew Conway helped Munster to a 36–22 bonus-point victory at home against Gloucester.

In the return leg away to Castres on 15 December, the French side won 13–12, with Joey Carbery scoring all of Munster's points from penalties.

[14] In round 6, Munster beat Exeter Chiefs 9–7 in Thomond Park on 19 January 2019 to advance to a record 18th Champions Cup quarter-final.

[17] Munster finished second in conference A in the 2018–19 Pro14 season, with 21 wins and 5 defeats,[18] and beat Italian side Benetton 15–13 in their quarter-final on 4 May 2019, to secure a semi-final against provincial rivals Leinster in the RDS on 18 May 2019.

Internationally, 13 Munster players represented Ireland during the season: Sammy Arnold, Tadhg Beirne, Joey Carbery, Andrew Conway, Keith Earls, Chris Farrell, Dave Kilcoyne, Niall Scannell, Conor Murray, Peter O'Mahony, CJ Stander, Darren Sweetnam and John Ryan.

11 players were involved in the Ireland under-20s team that won a grand slam during the 2019 Six Nations Under 20s Championship: Craig Casey, Seán French, Ben Healy, James McCarthy, Jonathan Wren and Josh Wycherley from the academy, and Jake Flannery, John Hodnett, Conor Phillips, Luke Masters and Billy Scannell were also involved.