The 2018–19 NCAA Division I women's basketball season began in November 2018 and concluded with the Final Four title game at Amalie Arena in Tampa, Florida, in April 2019.

The former Division II schools are ineligible for NCAA-sponsored postseason play until completing their D-I transitions in 2022.

In addition to the schools changing conferences, the 2018–19 season was the last for Savannah State in D-I with its decision to reclassify all of its sports to D-II.

Houston began the 2018–19 season at Texas Southern's Health and Physical Education Arena, where the Cougars played most of their 2017–18 home games.

The women played three home games at Texas Southern before moving into Fertitta Center.

For this list, an "upset" is defined as a win by a team seeded 7 or more spots below its defeated opponent.