The 2018–19 Penn State Lady Lions basketball team represented Pennsylvania State University during the 2018–19 NCAA Division I women's basketball season.

The Lady Lions, led by 12th-year head coach Coquese Washington, played their home games at the Bryce Jordan Center as members of the Big Ten Conference.

They lost in the first round of the Big Ten women's tournament to Wisconsin.

On March 9, Coquese Washington was fired as head coach.

She finished at Penn State with a 12-year record of 209–169.