The 2018–19 Pittsburgh Panthers women's basketball team represented Pittsburgh University during the 2018–19 NCAA Division I women's basketball season.

The Panthers, led by first year head coach Lane White, played their home games at the Petersen Events Center as members of the Atlantic Coast Conference.

They lost in the first round of the ACC women's tournament to Duke.

They lost in the first round of the ACC women's tournament to Wake Forest.

On April 5, the previous head coach Suzie McConnell-Serio was fired.