The 2018–19 Prairie View A&M Panthers basketball team represented Prairie View A&M University during the 2018–19 NCAA Division I men's basketball season.

The Panthers, led by third-year head coach Byron Smith, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference.

Therefore, they received an automatic bid to the NCAA tournament as a 16th seed.

Due to Grambling State's Academic Progress Rate violations and subsequent postseason ineligibility, the Panthers received the No.

They defeated Alcorn State in the quarterfinals before losing to Texas Southern in the semifinals.