[1] The reigning champions entering the season were Saracens, who had claimed their fourth title after defeating Exeter Chiefs in the 2018 final.
The competition was broadcast by BT Sport for the sixth successive season and with five games also simulcast free-to-air on Channel 5.
Saracens won their fifth title after defeating Exeter Chiefs in the final at Twickenham after having finished second in the regular season table.
Due to redevelopment work causing the closure of Twickenham Stadium, round 1 did not include the London Double Header.
It had previously been reported that Sale Sharks vs Harlequins in round 18 would take place at Toyota Park just outside Chicago, Illinois.