[7] They were joined by the six regular teams of West Indian domestic cricket (Barbados, Guyana, Jamaica, the Leeward Islands, Trinidad and Tobago, and the Windward Islands), the Combined Campuses and Colleges team and the West Indies B cricket team.

[3][8] On 6 October 2018, Chris Gayle played in his final List A cricket match for Jamaica, scoring a century, with Jamaica beating Barbados by 33 runs.

[12] In the second semi-final, Combined Campuses and Colleges beat Trinidad and Tobago by seven wickets, with Akeem Jordan taking a five-wicket haul.

[13] In the final, Combined Campuses and Colleges beat Guyana by six wickets to win their first Regional Super50 title.

[14][15] Prior to the start of the tournament, players were selected in the Professional Cricket League draft:[3][4][16][17] In September 2018, Cricket West Indies (CWI) confirmed the final squads for the tournament.