On 29 March 2019, Massy became the first side to be relegated, a narrow home defeat against Montauban condemning them to the drop with four games still left to play.

[1] The other relegation spot was much more keenly fought, going all the way to the last round, when on 5 May 2019 Bourg-en-Bresse were the second team to go down, despite winning their final game, just 1 point behind 14th placed Aurillac.

[3] In the final held at the Stade du Hameau, Pau, Bayaonne shaded a close game, 21–19, to win their first ever Pro D2 title and return to the Top 14 after an absence of two seasons.

[4] Defeated finalists Brive had a second shot at promotion when they faced 2018–19 Top 14 13th placed side, Grenoble, in the relegation playoff.

Changes in the lineup from 2017–18 were: The regular season uses a double round-robin format, in which each team plays the others home and away.

At the same time, LNR and the French Rugby Federation (FFR) changed the promotion process from Fédérale 1 to Pro D2.