The 2018–19 season was SPAL's second season in the top-flight of Italian football since 1968.

After being promoted as champions of Serie B in the 2016–17 season, SPAL finished just above the relegation places in 17th during the 2017–18 season.

The season was coach Leonardo Semplici's fifth in charge of the club, after taking over in December 2014.

On 3 July Semplici extended his contract with SPAL to 2020, with the option for a further year.

* Includes one shared clean sheet against Roma.