The 2018–19 season was Vitesse's 29th consecutive season in the top flight of Dutch football, the Eredivisie, and 126th year in existence as a football club.

Following the conclusion of the 2017–18 campaign, Vitesse announced they would play Wolfsberger AC, Shakhtar Donetsk, Arsenal Tula and Lokomotiv Moscow in July 2018.

Ten teams, two from the Eredivisie and eight from the Eerste Divisie, played for two spots in the 2019–20 Eredivisie, the remaining eight teams playing in the 2019–20 Eerste Divisie.

Source: Eredivisie The fixtures for the 2018–19 season were announced in June 2018.

[33] On 20 June 2018, the second qualifying round draw was confirmed with Vitesse facing the eventual winners of the first qualifying round tie between Racing FC and Viitorul Constanța in July and August.