The 2018–19 South Carolina Gamecocks women's basketball team represented the University of South Carolina during the 2018–19 NCAA Division I women's basketball season.

The Gamecocks, led by eleventh year head coach Dawn Staley, played their home games at the Colonial Life Arena and were members of the Southeastern Conference.

They received an at-large bid to the NCAA women's tournament where they defeated Belmont and Florida State in the first and second rounds before losing to Baylor in the Sweet Sixteen.

[1] They defeated North Carolina A&T and Virginia in the first and second rounds, Buffalo in the sweet sixteen before losing to Connecticut in the elite eight.

[2] Sources: Roster †Colonial Life Arena was being used for the First and Second Rounds of the 2019 NCAA Division I men's basketball tournament, so South Carolina hosted their games at Dale F. Halton Arena in Charlotte, North Carolina.