Barcelona were the defending champions, but were eliminated by Chelsea in the semi-finals, in a rematch of the previous season's final.

[41] The schedule of the competition is as follows (all draws are held at the UEFA headquarters in Nyon, Switzerland, unless stated otherwise).

For the Domestic Champions Path, the 32 teams were drawn into two rounds of two-legged home-and-away ties.

[46][47] There were no seedings, but the 32 teams were split into groups defined by sporting and geographical criteria prior to the draw.

In both rounds, if the aggregate score is tied after full time of the second leg, the away goals rule is used to decide the winner.

The draw for the round of 16 onwards was held on 22 February 2019, 14:00 CET (UTC+1), at the UEFA headquarters in Nyon, Switzerland.

[1] The draw for the knockout round play-offs was held on 17 December 2018, 14:15 CET (UTC+1), at the UEFA headquarters in Nyon, Switzerland.