The 2018–19 USC Trojans men's basketball team represented the University of Southern California during the 2018–19 NCAA Division I men's basketball season.

Led by sixth-year head coach Andy Enfield, they played their home games at the Galen Center in Los Angeles, California as members of the Pac-12 Conference.

2 seed in the Pac-12 tournament, they defeated Oregon State in the quarterfinals and Oregon in the semifinals before losing to Arizona in the championship game.

They were one of the last four teams not selected for the NCAA tournament and as a result earned a No.

1 seed in the National Invitation Tournament, where they defeated UNC Asheville in the first round before losing to Western Kentucky in the second round.