The 2018–19 Western Kentucky Lady Toppers basketball team represented Western Kentucky University during the 2018–19 NCAA Division I women's basketball season.

The Lady Toppers were led by first year head coach Greg Collins.

They played their home games at E. A. Diddle Arena and were members of Conference USA.

They advanced to the semifinals of the C-USA women's tournament, where they lost to Rice.

They received an at-large bid to the Women's National Invitation Tournament, where they defeated Miami (OH) and Morehead State in the first and second rounds before losing to Ohio in the third round.