The 2018–19 Women's EHF Challenge Cup was the 22nd edition of the European Handball Federation's third-tier competition for women's handball clubs, running from 10 November 2018.

All draws were held at the European Handball Federation headquarters in Vienna, Austria.

[1] The European Handball Federation has decided the last season’s runners-up and the 2016 winners Rocasa Gran Canaria ACE will be the only team, who are directly seeded for the Last 16 round.

The draw for the Last 16 took place at the EHF Office in Vienna on Thursday 22 November 2019.

Rocasa Gran Canaria ACE won 57–45 on aggregate.

The draw event was held at the EHF Office in Vienna on Tuesday 12 February 2019.

FT: 24–18 Pen: 2–3 Rocasa Gran Canaria ACE won 45–44 on aggregate.

The final home rights draw was held on 16 April 2019 in Vienna.