The 2018 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Big Sky Conference during the 2018 NCAA Division I FCS football season.
Led by tenth-year head coach Tim Walsh, Cal Poly compiled an overall record of 5–6 with a mark of 4–4 in conference play, tying for sixth place in the Big Sky.
On July 16, 2018 during the Big Sky Kickoff in Spokane, Washington, the Mustangs were predicted to finish in tenth place in the coaches poll and eleventh place in the media poll.
[1] The Mustangs had one player selected to the Preseason All-Conference Team.
[2] Joe Protheroe – Sr. FB The game with Weber State, fellow Big Sky Conference member, on September 8 was considered a non-conference game and had no effect on the Big Sky standings.