The 2018 East Tennessee State Buccaneers football team represented East Tennessee State University (ETSU) in the 2018 NCAA Division I FCS football season and were in the third year of their second stint as football members of the Southern Conference (SoCon).

They were led by first-year head coach Randy Sanders and played their home games at William B. Greene Jr.

They received an at-large bid to the FCS Playoffs, where they lost to Jacksonville State in the first round.

The SoCon released their preseason media poll on July 25, 2018, with the Buccaneers predicted to finish in eighth place.

[2] The same day the coaches released their preseason poll with the Buccaneers also predicted to finish in eighth place.