The first round of CONCACAF matches for 2018 FIFA World Cup qualification was played between 22 and 31 March 2015.

The draw for the first round was held on 15 January 2015, 19:40 EST (UTC−5), at the W Hotel at Miami Beach, Florida, United States.

[3] The seeding was based on the FIFA World Rankings of August 2014 (shown in parentheses).

Saint Kitts and Nevis won 12–4 on aggregate and advanced to the second round against El Salvador.

Belize won on the away goals rule and advanced to the second round against Dominican Republic.