The fourth round of CONCACAF matches for 2018 FIFA World Cup qualification was played from 13 November 2015 to 6 September 2016.
[1] The draw for the fourth round was held as part of the 2018 FIFA World Cup Preliminary Draw on 25 July 2015, starting 18:00 MSK (UTC+3), at the Konstantinovsky Palace in Strelna, Saint Petersburg, Russia.
[1][3][4] The seeding was based on the FIFA World Rankings of August 2014 (shown in parentheses).
The fixtures of each group were automatically decided based on the respective pot or series won of each team.
Note: Bolded teams qualified for the fifth round.