The 2018 FIFA World Cup CONCACAF–AFC qualification play-off was a two-legged home-and-away tie between the fourth-placed team from the CONCACAF fifth round, Honduras, and the winner of the AFC fourth round play-off, Australia.

Australia therefore qualified for the 2018 FIFA World Cup finals, reaching the tournament for the fifth time, and fourth in succession.

This was also their second play-off appearance as an AFC member, and the first since 1974 (in which Australia qualified for the first time for the tournament).

This was Honduras' first participation in the inter-confederation play-offs; they finished fourth in the final round of the CONCACAF qualification after the United States lost to Trinidad and Tobago 2–1, which caused the United States to not qualify for the World Cup for the first time since 1986.

[2] Assistant referees: Lorenzo Manganelli (Italy) Riccardo di Fiore (Italy) Fourth official: Paolo Tagliavento (Italy) Assistant referees: Hernán Maidana (Argentina) Juan Pablo Belatti (Argentina) Fourth official: Patricio Loustau (Argentina)