Simona Halep defeated Sloane Stephens in the final, 3–6, 6–4, 6–1 to win the women's singles tennis title at the 2018 French Open.

Halep was the second Romanian woman to win a major singles title, after Virginia Ruzici in 1978.

This made her only the second French Open champion (after Anastasia Myskina in 2005) to lose in the first round of their title defense.

This tournament marked the first time that Agnieszka Radwańska did not play in the main draw of a singles major since her debut at the 2006 Wimbledon Championships, ending a streak of 47 consecutive appearances.

[9] Williams reached the fourth round before withdrawing due to a pectoral muscle injury, ending her streak of ten consecutive major semifinals dating back to the 2014 US Open.