The 2018 Indiana State Sycamores football team represented Indiana State University in the 2018 NCAA Division I FCS football season.

They were led by second-year head coach Curt Mallory and played their home games at Memorial Stadium.

Despite being ranked in the top 25 at the end of the regular season, they were not selected to participate in the FCS Playoffs.

The MVFC released their preseason poll on July 29, 2018, with the Sycamores predicted to finish in last place.

[2] Offense 2nd team Jerry Nunez – K Defense 2nd team Inoke Moala – DL Derrek Tuszka – DL Jonas Griffith – LB Katrell Moss – LB Rondell Green – DB