The 2018 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts.

It was the sixth edition of the tournament which was part of the 2018 ATP Challenger Tour.

It took place in Mouilleron-le-Captif, France between 5 and 11 November 2018.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as special exempts: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: