The 2018 Ladies Open Lugano (also known as the 2018 Samsung Open presented by Cornèr for sponsorship reasons) was a women's tennis tournament played on clay courts at TC Lido Lugano.

It was the second edition of the tournament (the first to take place in Lugano) and part of the International category of the 2018 WTA Tour.

[1] It took place between 9 April through 15 April 2018.

[2] The following players received wildcards into the main draw: The following players received entry using a protected ranking into the main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pair received a wildcard into the main draw: The following pair received entry as alternates: