The 2018 Lilly Diabetes 250 was a NASCAR Xfinity Series race held on September 10, 2018 at Indianapolis Motor Speedway in Speedway, Indiana.

[3] Contested over 100 laps on the 2.5-mile (4.0 km) speedway, it was the 25th race of the 2018 NASCAR Xfinity Series season.

Both practice sessions for the race were cancelled due to rain.

[4] Qualifying for the race was cancelled due to rain.

Ryan Blaney won the pole based on owner's points.