The 2018 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2018 NCAA Division I FCS football season.

Led by Lance Guidry in his third and final season as head caoach, the Cowboys compiled an overall record of 6–5 with a mark of 5–4 in conference play, placing in four-way tie for fourth in the Southland.

McNeese State played home games at Cowboy Stadium in Lake Charles, Louisiana.

On July 12, 2018, the Southland announced their Preseason All-Conference Teams, with the Cowboys having ten players selected.

at Gayle and Tom Benson Stadium, San Antonio, TX