[3] In January 2018, the Wolverines hired Ben Herbert as Director of strength and conditioning, and Sherrone Moore as tight ends coach.

The offensive coordinator position remained vacant throughout the 2018 season, with play calling duties split among the offensive coaches in what coach Harbaugh described as a "collaborative effort", with passing game coordinator Pep Hamilton calling a majority of the plays.

[25] Sources: [26] To open the season, Michigan travelled to South Bend, Indiana to face the Notre Dame Fighting Irish to resume its long-running rivalry after a three year hiatus.

Michigan responded with 10 points in the second quarter on a 28-yard field goal by Quinn Nordin and a 99-yard kickoff return by Ambry Thomas.

Michigan reduced Notre Dame's lead to seven points following a three-yard touchdown run from Karan Higdon in the fourth quarter.

Michigan's defense held Notre Dame to only 69 yards on 29 plays and three points in the second half, and scoreless in the fourth quarter.

Michigan added seven points in the fourth quarter on an 18-yard touchdown pass from Dylan McCaffrey to Jake McCurry.

Western Michigan finally got on the board late in the fourth quarter with a 35-yard field goal by Josh Grant to avoid a shutout.

Michigan's defense held its opponent to single-digit points for the first time since allowing just a field goal to Maryland in 2016.

Michigan extended its lead with a 45-yard field goal by Quinn Nordin and a nine-yard touchdown run from Tru Wilson.

Nebraska finally got on the board late in the third quarter with a 35-yard field goal by Barret Pickering to avoid a shutout.

The last time the Michigan defense held an opponent to negative rushing yards in a quarter was against Ohio State in 2017.

[51] Northwestern scored ten points in the first quarter, on a one-yard touchdown run from Clayton Thorson and a 45-yard field goal by Charlie Kuhbande.

Michigan finally got on the board with a four-yard touchdown run from Karan Higdon, which made the score 17–7 in favor of Northwestern at half-time.

Michigan extended its lead in the third quarter on a 31-yard field goal by Nordin and a 34-yard touchdown pass from Patterson to Donovan Peoples-Jones.

Michigan added 15 points in the fourth quarter on a seven-yard touchdown pass from Patterson to Jared Wangler, and a two-point conversion Mason run, and a 46-yard interception return by Brandon Watson.

Michigan extended its lead in the third quarter on a seven-yard touchdown run from Shea Patterson, followed by a two-point conversion pass to Nico Collins.

First with a 35-yard field goal by Nordin, then a 21-yard interception return from Lavert Hill and a 44-yard touchdown run from Dylan McCaffrey.

Michigan added 14 points in the third quarter on a seven-yard touchdown pass from Patterson to Zach Gentry and a 62-yard interception return by Brandon Watson.

Penn State finally got on the board late in the fourth quarter on an eight-yard touchdown run from Tommy Stevens to avoid a shutout.

This is the second-longest streak in Michigan program history, trailing only Mike Hart's eight consecutive games with 100-yards rushing in 2007.

[69] After hosting Penn State, Michigan traveled to Piscataway, New Jersey to face the Rutgers Scarlet Knights.

He became the first 1,000-yard running back for Michigan since Fitzgerald Toussaint in 2011, and the first player of any kind to rush for over 1,000 yards since Denard Robinson in 2012.

Michigan added 12 points during the second quarter on two field goals by Moody, from 30-yards, and 31-yards respectively, and a 41-yard touchdown pass from Shea Patterson to Nick Eubanks.

Michigan added 10 points in the third quarter on a two-yard touchdown run from Karan Higdon and a 33-yard field goal by Moody to regain the lead.

[81] Freshman kicker Jake Moody set a Michigan single-game record with six field goals, going 6-for-6 in his collegiate placekicking debut.

[83] Ohio State opened the scoring in the first quarter with a 24-yard touchdown pass from Dwayne Haskins to Chris Olave.

Ohio State scored 17 points in the quarter on a 24-yard touchdown pass from Haskins to Olave, a 31-yard touchdown pass from Haskins to Johnnie Dixon and a 19-yard field goal by Blake Haubeil as time expired, which made the score 24–19 in favor of Ohio State at half-time.

Ohio State added 17 points in the third quarter on a 19-yard field goal by Haubeil, a 33-yard punt return by Sevyn Banks and a two-yard touchdown run from Mike Weber.

[94][95] Former Michigan starting quarterback Wilton Speight, who grad transferred to UCLA before the 2018 season, also signed as an undrafted free agent with the San Francisco 49ers.