The Twins began the season on March 29 on the road against the Baltimore Orioles and ended the season at home against the Chicago White Sox.

[1] The Twins finished the 2018 season at 78–84, 13 games out of first place in a weak American League Central.

The record led to the firing of manager Paul Molitor the day after the season ended.

Infielders Outfielders Coaches Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average Source:[1] Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts Source:[2] The Twins played two games against the Cleveland Indians on April 17 and 18 at Hiram Bithorn Stadium in San Juan, Puerto Rico.

[2] An island-wide power outage occurred on April 18, but the game scheduled for that day was still played.