The 2018 Mutua Madrid Open was a professional tennis tournament played on outdoor clay courts at the Park Manzanares in Madrid, Spain from 5–13 May 2018.

Seedings are based on ATP rankings as of 30 April 2018.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following are the seeded players.

Seedings are based on WTA rankings as of 30 April 2018.

The following players received wildcards into the main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pairs received entry as alternates: