The Mets began the regular season on March 29, 2018, with their home opener with a 9–4 win over the St. Louis Cardinals at Citi Field in Queens, New York.

They snapped their 8–game losing streak by beating their crosstown rivals, the New York Yankees 2–0 in the last game of the three-game Subway Series, handing the Bronx Bombers their first shutout loss of the season.

The Mets finished the month 5–21, second to last place in the NL East behind their division rivals, the Miami Marlins, losing the first two games of the series to them.

The highlight of the series, the Mets beat the Phillies 8–2 in the second annual Little League Classic at BB&T Ballpark in Williamsport, PA.

The month ended with the Mets losing against the San Francisco Giants 7–0, finishing August with equal wins and losses at 15–15.

The Mets then played a rainy four-game series against the last-place Miami Marlins managing to win three out of four; the one loss by the NL Cy Young candidate Jacob deGrom.

The Mets then traveled back home to take two of three against the Atlanta Braves, and began the final series of the season against the Marlins.

After an 8–1 loss in the series opener, former Mets team captain and third baseman David Wright played the final game of his career on the following day.

He batted 0-for-1 with a walk and fielded one ground ball before being removed in the fifth inning to a lengthy ovation by many Mets fans and players alike.