The 2018 Northwestern State Demons football team represented Northwestern State University as a member of the Southland Conference during the 2018 NCAA Division I FCS football season.

Led by first-year head coach Brad Laird, the Demons compiled an overall record of 5–6 with a mark of 4–5 in conference play, tying for eighth place in the Southland.

Northwestern State played home games at Harry Turpin Stadium in Natchitoches, Louisiana.

On July 19, 2018, the Southland announced their preseason poll, with the Demons predicted to finish in eighth place.

at Anthony Field at Wildcat Stadium, Abilene, TX