The 2018 Oklahoma State Cowboys football team represented Oklahoma State University in the 2018 NCAA Division I FBS football season.

The Cowboys played their home games at the Boone Pickens Stadium in Stillwater, Oklahoma and competed in the Big 12 Conference.

They were invited to the Liberty Bowl where they defeated #24 Missouri 38-33, ending the season with a 4-1 record against teams in the top 25.

[9] Iowa State's Freshman Brock Purdy replaced Zeb Noland at quarterback and passed 18-for-23 for 318 yards and produced four touchdowns.

[12] The previous week loss against Iowa State put extra pressure on the Cowboys to win coming into the game against Kansas State.