The Monarchs played their home games at the Foreman Field in Norfolk, Virginia as members of the East Division of Conference USA (C–USA).

ODU had sold out every home game since they restarted the football program in 2009.

[9] Defense Oshane Ximines – DL Special teams Isaiah Harper – KR Darrell Brown – PR

Conference USA released their preseason media poll on July 17, 2018, with the Monarchs predicted to finish in sixth place in the East Division.

[10] This marked Old Dominion's first win over a Power Five program in their FBS history.