The 2018 Penn Quakers football team represented the University of Pennsylvania during the 2018 NCAA Division I FCS football season.

They were led by fourth-year head coach Ray Priore and played their home games at Franklin Field.

They were a member of the Ivy League.

They finished the season 6–4 overall 3–3 in Ivy League play to place in a three-way tie for fourth.

Penn averaged 7,767 fans per game.