The 2018 Texas A&M–Commerce Lions football team represented Texas A&M University–Commerce in the 2018 NCAA Division II football season.

They were led by head coach Colby Carthel, who was in his sixth season at Texas A&M–Commerce.

The Lions played their home games at Memorial Stadium and were members of the Lone Star Conference.

The Lions finished the regular season with a record of 9–2 and second place in the conference.

The team made the NCAA Division II playoffs, losing in the regional semifinal to Tarleton State.