Novak Djokovic defeated Juan Martín del Potro in the final, 6–3, 7–6(7–4), 6–3 to win the men's singles tennis title at the 2018 US Open.

3 and 2013 French Open finalist David Ferrer; he retired from his first round match against Nadal due to injury.

1 Andy Murray participated, entering with a protected ranking.

This marked the first time in the tournament's history that seven former champions competed: Federer, del Potro, Nadal, Djokovic, Murray, Marin Čilić and Stan Wawrinka.

Peter Polansky was the first player to qualify for the main draw of all four majors as a lucky loser in a calendar year.